姓名：朱江

职称：校聘教授

邮箱：jiangzhu@sdau.edu.cn

个人简介

朱江，男，博士，教授，博士生导师。2015年毕业于东北农业大学获理学博士学位，随后在美国罗切斯特大学医学中心和同济大学生命科学与技术学院从事博士后研究。主要研究方向为哺乳动物配子及早期胚胎发育的表观遗传调控机制，主持国家自然青年科学基金、杨浦区博士后创新基金，获授权发明专利1项，先后在Nature Communications、Nature Cell Biology、SCIENCE CHINA Life Sciences、Development、Human Reproduction、Aging (Albany NY)等SCI期刊发表论文二十余篇。

教育经历

2018 - 2021,博士后,细胞干性与命运编辑,同济大学

2016 - 2018,博士后,piRNA生物合成,罗切斯特大学医学中心

2012 - 2015,理学博士,发育生物学专业,东北农业大学

2009 - 2012,理学硕士,发育生物学专业,东北农业大学

2005 - 2009,理学学士,生物技术专业,东北农业大学

工作经历

2025 - 至今,教授,山东农业大学威尼斯wns·8885556

2021 - 2024,研发经理,上海金跃生物科技有限公司

2015 - 2016,胚胎师,上海交通大学附属第九人民医院

研究领域

本实验室主要研究领域：

1.大动物早期胚胎细胞谱系发生过程与调控机制的研究

2.大动物干细胞系与人工胚胎技术体系的建立与优化

3.大动物疾病模型的建立与应用

承担的科研项目：

1.RNA降解相关蛋白Lsm1在多能性调控过程中的作用和机制研究，国家自然青年科学基金，2020-2022，主持

2.eccDNA技术在临床诊断中的应用研究，杨浦区博士后创新基金，2020-2021主持

发表文章、专利

1. Chen, K., Liu, W., Zhu, J., Kou, X., Zhao, Y., Wang, H., Jiang, C., Gao, S., and Kang, L. (2024). Pivotal role for long noncoding RNAs in zygotic genome activation in mice. Sci China Life Sci 67, 958-969 (2024). (contribute equally)

2. Zhu, J., Chen, K., Sun, Y.H., Ye, W., Liu, J., Zhang, D., Su, N., Wu, L., Kou, X., Zhao, Y., et al. (2023). LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei. Nat Commun 14, 957.

3. Sun, Y.H., Wang, R.H., Du, K., Zhu, J., Zheng, J., Xie, L.H., Pereira, A.A., Zhang, C., Ricci, E.P., and Li, X.Z. (2021). Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs. Nat Commun 12, 5970.

4. Sun, Y.H., Zhu, J., Xie, L.H., Li, Z., Meduri, R., Zhu, X., Song, C., Chen, C., Ricci, E.P., Weng, Z., et al. (2020). Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors. Nat Cell Biol 22, 200-212.

5. Wang, T.Y., Zhang, J., Zhu, J., Lian, H.Y., Yuan, H.J., Gao, M., Luo, M.J., and Tan, J.H. (2017). Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes. Aging (Albany NY) 9, 1186-1201.

6. Bou, G., Liu, S., Sun, M., Zhu, J., Xue, B., Guo, J., Zhao, Y., Qu, B., Weng, X., Wei, Y., et al. (2017). CDX2 is essential for cell proliferation and polarity in porcine blastocysts. Development 144, 1296-1306.

7. Tan, X.W., Ji, C.L., Zheng, L.L., Zhang, J., Yuan, H.J., Gong, S., Zhu, J., and Tan, J.H. (2017). Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study. Hum Reprod 32, 1583-1597.

8. Huan, Y.J., Wu, Z.F., Zhang, J.G., Zhu, J., Xie, B.T., Wang, J.Y., Li, J.Y., Xue, B.H., Kong, Q.R., and Liu, Z.H. (2016). Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos. J Reprod Dev 62, 71-77.

9. Zhu, J., Lin, F.H., Zhang, J., Lin, J., Li, H., Li, Y.W., Tan, X.W., and Tan, J.H. (2016). The signaling pathways by which the Fas/FasL system accelerates oocyte aging. Aging (Albany NY) 8, 291-303.

10. Lin, J., Chen, F., Sun, M.J., Zhu, J., Li, Y.W., Pan, L.Z., Zhang, J., and Tan, J.H. (2016). The relationship between apoptosis, chromatin configuration, histone modification and competence of oocytes: A study using the mouse ovary-holding stress model. Sci Rep 6, 28347.

11. Huan, Y., Wu, Z., Zhang, J., Zhu, J., Liu, Z., and Song, X. (2015). Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. PLoS One 10, e0129803.

12. Zhu, J., Zhang, J., Li, H., Wang, T.Y., Zhang, C.X., Luo, M.J., and Tan, J.H. (2015). Cumulus cells accelerate oocyte aging by releasing soluble Fas ligand in mice. Sci Rep 5, 8683.

13. Huan, Y., Zhu, J., Huang, B., Mu, Y., Kong, Q., and Liu, Z. (2015). Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. PLoS One 10, e0126607.

14. Huan, Y., Wang, H., Wu, Z., Zhang, J., Zhu, J., Liu, Z., and He, H. (2015). Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. Cell Reprogram 17, 191-198.

15. Huan, Y., Hu, K., Xie, B., Shi, Y., Wang, F., Zhou, Y., Liu, S., Huang, B., Zhu, J., Liu, Z., et al. (2015). Ovulation Statuses of Surrogate Gilts Are Associated with the Efficiency of Excellent Pig Cloning. PLoS One 10, e0142549.

16. Wang, T.Y., Li, Q., Li, Q., Li, H., Zhu, J., Cui, W., Jiao, G.Z., and Tan, J.H. (2014). Non-frozen preservation protocols for mature mouse oocytes dramatically extend their developmental competence by reducing oxidative stress. Mol Hum Reprod 20, 318-329.

17. Zhang, C.X., Cui, W., Zhang, M., Zhang, J., Wang, T.Y., Zhu, J., Jiao, G.Z., and Tan, J.H. (2014). Role of Na+/Ca2+ exchanger (NCX) in modulating postovulatory aging of mouse and rat oocytes. PLoS One 9, e93446.

18. Huan, Y.J., Zhu, J., Wang, H.M., Wu, Z.F., Zhang, J.G., Xie, B.T., Li, J.Y., Kong, Q.R., Liu, Z.H., and He, H.B. (2014). Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. J Reprod Dev 60, 377-382.

19. Bou, G., Sun, M., Lv, M., Zhu, J., Li, H., Wang, J., Li, L., Liu, Z., Zheng, Z., He, W., et al. (2014). A pre-breeding screening program for transgenic boars based on fluorescence in situ hybridization assay. Transgenic Res 23, 679-689.

20. Huan, Y.J., Zhu, J., Xie, B.T., Wang, J.Y., Liu, S.C., Zhou, Y., Kong, Q.R., He, H.B., and Liu, Z.H. (2013). Treating cloned embryos, but not donor cells, with 5-aza-2'-deoxycytidine enhances the developmental competence of porcine cloned embryos. J Reprod Dev 59, 442-449.

21. Zhang, L., Luo, Y.B., Bou, G., Kong, Q.R., Huan, Y.J., Zhu, J., Wang, J.Y., Li, H., Wang, F., Shi, Y.Q., et al. (2011). Overexpression Nanog activates pluripotent genes in porcine fetal fibroblasts and nuclear transfer embryos. Anat Rec (Hoboken) 294, 1809-1817.

22. Kong, Q.R., Zhu, J., Huang, B., Huan, Y.J., Wang, F., Shi, Y.Q., Liu, Z.F., Wu, M.L., and Liu, Z.H. (2011). [TSA improve transgenic porcine cloned embryo development and transgene expression]. Yi Chuan 33, 749-756. (contribute equally)

23. Wei, Y., Zhu, J., Huan, Y., Liu, Z., Yang, C., Zhang, X., Mu, Y., Xia, P., and Liu, Z. (2010). Aberrant expression and methylation status of putatively imprinted genes in placenta of cloned piglets. Cell Reprogram 12, 213-222.

24.国家实用新型专利：一种实验用动物饲养笼具，批准年份:2024，专利号: CN222263953U，发明人: 高懿, 朱江, 张振天。