个人简介

王恒，教授，博士生导师，“千人计划”青年专家，泰山学者。现任山东省家畜种质创新与利用重点实验室主任，山东省青年创新团队负责人，动物生物技术专业主任等。研究方向为畜禽功能基因组，主攻猪产肉和肉质性状形成的生物学基础，肌肉发育和再生的分子机理和表观调控机制等。以通讯或第一作者在Cell Stem Cell，Nature Communications，eLife，Cell Reports等杂志发表多篇论文，主持国家自然科学基金，国家重点研发计划课题等多个项目，获授权专利6项，任Cell Regeneration期刊编委。

联系方式

wangheng@sdau.edu.cn

教育经历

2009 - 2016 , 博士后 , 细胞与分子生物学 , Karolinska Institutet

2007 - 2008 , 博士后 , 动物科学与人类营养学, University of Hawaii

2002 - 2007 , 博士, 动物遗传育种与繁殖, 华中农业大学

1998 - 2002 , 本科，动物科学 , 华中农业大学

工作经历

2022 - 至今 , 教授 , 山东农业大学

2017 - 2021 , 教授 , 华中农业大学

执教课程

动物遗传学，分子生物学（本科生）

基因编辑技术，动物生物技术（研究生）

研究领域

1. 生猪产肉和肉质性状形成的生物学基础

2. 肌肉发育与再生的分子调控机制

代表性成果

1. Liao Y, Peng Z, Fu S, Hua Y, Luo W, Liu R, Chen Y, Gu W, Zhao P, Zhao J, Wang Y, Wang H*. Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation. Journal of Advanced Research. S2090-1232(24)00624-6. (2024)

2. Ma T, Ren R, Lv J, Yang R, Zheng X, Hu Y, Zhu G, Wang H*. Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition. eLife. 13, RP93220. (2024)

3. Yin B, Zhang K, Du X, Cai H, Ye T, Wang H*. Developmental switch from morphological replication to compensatory growth for salamander lung regeneration. Cell Proliferation. 56 (3)：e13369 (2023)

4. Ren R, Fan Y, Peng Z, Wang S, Jiang Y, Fu L, Cao J, Zhao S, Wang H*. Characterization and perturbation of CTCF-mediated chromatin interactions for enhancing myogenic transdifferentiation. Cell Reports. 40(7):111206. (2022)

5. Wang S, Liao Y, Zhang H, Jiang Y, Peng Z, Ren R, Li X, Wang H*. Tcf12 is required to sustain myogenic genes synergism with MyoD by remodelling the chromatin landscape. Communications Biology. 5(1):1201. (2022)

6. Luo W, Xu Y, Liu R, Liao Y, Wang S, Zhang H, Li X, Wang H*. Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation. Cell Death Disease. 13(9):838. (2022)

7. Peng Z, Yin B, Ren R, Liao Y, Cai H, Wang H*. Altered metabolic state impedes limb regeneration in salamanders. Zoological Research. 42(6):772-782. (2021)

8. Yin B, Ren H, Cai H, Jiang Y, Zhao S, Wang H*. Dynamics of cardiomyocyte and muscle stem cell proliferation in pig. Experimental Cell Research. 388(2). 111854. (2020)

9. Elewa A, Wang H (co-first), Talavera-López C, Joven A, Brito G, Kumar A, Hameed LS, Penrad-Mobayed M, Yao Z, Zamani N, Abbas Y, Abdullayev I, Sandberg R, Grabherr M, Andersson B, Simon A. Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration. Nature Communications. 8(1):2286. (2017)

10. Wagner I, Wang H (co-first), Weissert PM, Straube WL, Shevchenko A, Gentzel M, Brito G, Tazaki A, Oliveira C, Sugiura T, Shevchenko A, Simon A, Drechsel DN, Tanaka EM. Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration. Developmental Cell. 40(6):608-617. (2017)

11. Wang H, Simon A. Skeletal muscle dedifferentiation during salamander limb regeneration. Current Opinion in Genetics and Development. 40, 108-112. (2016)

12. Wang H, Loof S, Borg P, Nader G, Blau HM, Simon A. (2015). Turning terminally differentiated skeletal muscle cells into regenerative progenitors. Nature Communications. 6, 7916. (2015)

13. Sandoval-Guzmán T, Wang H (co-first), Khattak S, Schuez M, Roensch K, Nacu E, Tazaki A, Joven A, Tanaka EM, Simon A. Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species. Cell Stem Cell. 14(2):174-187. (2014)

14. 尹彬旭，王恒. Yap在哺乳动物内脏器官再生中的研究进展。中国细胞生物学报。44(8):1520-1528. (2022)

15. 两条特异性靶向猪Pax7基因的sgRNA导向序列及应用。王恒等，ZL202011415603