姓名：樊瑞锋

职称：副教授

邮箱：fanruifeng@sdau.edu.cn

个人简介

樊瑞锋，博士，副教授，硕士研究生导师，山东农业大学“1512”第三层次人才。担任中国畜牧兽医学会兽医内科与临床诊疗学分会理事。主要从事畜禽营养代谢病与中毒病方面的教学与研究工作，擅长宠物与奶牛疾病的诊疗。

主持及参与国家自然科学基金、中国博士后科学基金、山东省自然科学基金项目5项；发表SCI期刊收录论文40余篇；副主编《图说鸡病诊治》，参编《奶牛异常症状的鉴别诊断与治疗》，参译《小动物CT与MRI图谱》；担任Ecotoxicology and Environmental Safety、Science of the Total Environment、Environmental Pollution、International Journal of Biological Macromolecules、Biological Trace Element Research等国外杂志审稿专家。

教育经历

2014 – 2017 ，兽医博士 ，兽医专业 ，东北农业大学

2011 – 2014 ，农学硕士 ，临床兽医学专业 ，山东农业大学

2007 – 2011 ，农学学士 ，动物医学专业 ，山东农业大学

工作经历

2017 – 至今 ，副教授 ，山东农业大学

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执教课程

1. 本科生：兽医内科学、小动物疾病学、动物医学研究进展

2. 硕士研究生：动物临床疾病诊疗

研究领域

主要研究领域：
     1. 硒与硒蛋白生物学功能研究
     2. 重金属、有机毒物毒性机理及解毒机制研究

承担的科研项目：

1. 山东农业大学引进人才科研启动基金项目，主持，2017年度

2. 山东省自然科学基金博士基金项目，主持，2018年度

3. 国家自然科学基金青年基金项目，主持，2019年度

4. 中国博士后科学基金面上项目，主持，2020年度

5. 国家自然科学基金面上项目，主持，2022年度

发表文章、专利

1.Chu J. H., Li L. X., Gao P. C., Chen X. W., Wang Z. Y., Fan R. F.. Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy. Free radical biology & medicine. 2022;188:35-44.

2.Chen X. W., Chu J. H., Li L. X., Gao P. C., Wang Z. Y., Fan R. F.. Protective mechanism of selenium on mercuric chloride-induced testis injury in chicken via p38 MAPK/ATF2/iNOS signaling pathway. Theriogenology. 2022;187:188-194.

3.Li L. X., Chu J. H., Chen X. W., Gao P. C., Wang Z. Y., Liu C., Fan R. F.. Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways. Journal of inorganic biochemistry. 2022;229:111716.

4.Gao P. C., Chen X. W., Chu J. H., Li L. X., Wang Z. Y., Fan R. F.. Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA-183/135b-FOXO1/TXNIP/NLRP3 inflammasome axis. Environmental toxicology. 2022;37(5):1047-1057.

5.Gao P. C., Chu J. H., Chen X. W., Li L. X., Fan R. F.. Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF-κB/NLRP3 inflammasome-mediated inflammation. Ecotoxicology and environmental safety. 2021;228:113018.

6.Fan R. F., Tang K. K., Wang Z. Y., Wang L. Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury. Toxicology. 2021;464:152999.

7.Chu J. H., Yan Y. X., Chen X. W., Gao P. C., Li L. X., Fan R. F.. Aberrant Gene Expression of Selenoproteins in Chicken Spleen Lymphocytes Induced by Mercuric Chloride. Biological trace element research. 2022;200(6):2857-2865.

8.Fan R. F., Li Z. F., Zhang D., Wang Z. Y.. Involvement of Nrf2 and mitochondrial apoptotic signaling in trehalose protection against cadmium-induced kidney injury. Metallomics : integrated biometal science. 2020;12(12):2098-2107.

9.Fan R. F., Liu J. X., Yan Y. X., Wang L., Wang Z. Y.. Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride. Poultry science. 2020;99(11):5430-5439.

10.Chu J. H., Yan Y. X., Gao P. C., Chen X. W., Fan R. F.. Response of selenoproteins gene expression profile to mercuric chloride exposure in chicken kidney. Research in veterinary science. 2020;133:4-11.

11.Tang K. K., Liu X. Y., Wang Z. Y., Qu K. C., Fan R. F.. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. Metallomics : integrated biometal science. 2019;11(12):2043-2051.

12.Tang K. K., Li H. Q., Qu K. C., Fan R. F.. Selenium alleviates cadmium-induced inflammation and meat quality degradation via antioxidant and anti-inflammation in chicken breast muscles. Environmental science and pollution research international. 2019;26(23):23453-23459.

13.Qu K. C., Wang Z. Y., Tang K. K., Zhu Y. S., Fan R. F.. Trehalose suppresses cadmium-activated Nrf2 signaling pathway to protect against spleen injury. Ecotoxicology and environmental safety. 2019;181:224-230.

14.Qu K. C., Li H. Q., Tang K. K., Wang Z. Y., Fan R. F.. Selenium Mitigates Cadmium-Induced Adverse Effects on Trace Elements and Amino Acids Profiles in Chicken Pectoral Muscles. Biological trace element research. 2020;193(1):234-240.

15.Fan R. F., Cao C. Y., Chen M. H., Shi Q. X., Xu S. W.. Gga-let-7f-3p promotes apoptosis in selenium deficiency-induced skeletal muscle by targeting selenoprotein K. Metallomics : integrated biometal science. 2018;10(7):941-952.

16.Fan R. F., Yao H. D., Cao C. Y., Zhao X., Khalid A., Zhao J. X., Zhang Z. W., Xu S. W.. Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts. Biological trace element research. 2017;180(1):135-145.

17.Fan R. F., Yao H. D., Zhao X., Cao C. Y., Yang T. S., Luan Y. L., Zhang Z. W., Xu S. W.. Gene expression of selenoproteins can be regulated by selenoprotein K silencing in chicken myoblasts. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2016;29(4):679-689.