张桂国

职称：教授

邮箱：zhanggg@sdau.edu.cn

办公室电话：0538-8241544-8327

个人主页：https://www.researchgate.net/profile/Guiguo-Zhang-3

个人简介

张桂国，教授，博士生导师，学科点负责人。山东省牧草产业体系岗位科学家（饲草营养岗），山东畜牧兽医学会副秘书长，反刍动物科技专业委员会主任委员，草业科技专业委员会秘书长。先后在美国加州大学戴维斯分校、新西兰皇家农业科学院、新西兰林肯大学、北京大学生命科学院做访问学者。担任Nutrition Research and Practice杂志编委；近五年，以第一或通讯作者发表SCI论文30余篇。获山东省科技进步二等奖2项、神农中华农业科技奖2项，发明专利4项，主持制定山东省地方标准7项。主持国家重点研发计划，山东省牧草产业体系，山东省良种工程，农业农村部行业专项等重大科研项目10余项。

教育经历

工作经历

荣誉奖励

山东省青年骨干教师 , 2014年

执教课程

分子营养（博士）

饲料科学、新型饲料添加剂（硕士）

Animal nutrition（英文）（本科生 中美合作培养）

饲料分析 （本科生）

研究领域

本实验室主要研究领域

1.组学营养：利用组学技术研究膳食纤维（植物多糖）/饲料养分通过调控肠道微生物组、代谢组的途径来影响宿主生理、生长发育状态的内在机制；

2.营养与代谢：饲料养分、植物功能性成分的代谢规律及对畜产品品质调控的组学机制；

3.牧草产业：青贮玉米及优质牧草品种选育、高效生产技术；草畜一体化建设关键技术的研究、集成与示范。

承担的科研项目

1. 主持   国家重点研发项目 “陆生/海洋植物中功能性多糖构效关系与生物学活性分子机制研究（2019YFE0107700）2020.7-2023.6。

2. 山东省牧草产业体系岗位科学家  饲草营养岗位 （SDAIT-23-05） 2021-2025年；

3. 国家十三五重大研发计划（子课题）  肉羊健康养殖2018YFD0502104-3    2018-2020；

2. 农业部“粮改饲”重大专项   青贮玉米在肉羊健康养殖中的应用  2018-2022年；

3. 山东省农业良种工程“南种北繁”项目 LZ201712080160    2018-2022；

4. 山东省农业重大应用技术创新项目 《粮改饲高产高效生产利用模式与关键技术的集成示范》  2018-2022；

5. 山东省良种工程项目“黄河三角洲肉用绵羊青粗饲料供应综合配套技术研究”（2021-2023，周期滚动项目）；

发表文章 (第一或通讯作者文章)

1.Chongyu Zhang, Eunyoung Kim, Jiamei Cui, Yunpeng Wang, Yunkyoung Lee*,Guiguo Zhang*. Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.). Food and Function. 2022, 4. Q1, 2Top, IF= 6.317.

2.Guiguo Zhang*, Yunkyoung Lee*, Zeng-Yu Wang and Yuxi Wang. Editorial: Synthesis and Bioactivities of Plant-Derived Biomolecules Frontiers in plant science.2022, 7. Q1, Top, IF= 6.627.

3.Guiguo Zhang^*, Yunkyoung Lee ^*, Yang Liu, and Yanlin Hao. Editorial: The Mechanism of Plant-derived Polysaccharides Regulating the Obesity and Metabolic Diseases in Humans. Frontiers in nutrition. 2022, 8. Q1, Top, IF= 6.59.

4.Jiamei Cui, Yunpeng Wang, Eunyoung Kim, Chongyu Zhang, Guiguo Zhang*, Yunkyoung Lee* Structural characteristics and immunomodulatory effects of a long-chain polysaccharide from Laminaria Japonica. Frontiers in nutrition. 2022, 3. Q1, 1 Top, IF= 6.59.

5.Siqi Li, Meiyu Du, Chongyu Zhang, Yun Wang, Yunkyoung Lee*, Guiguo Zhang* Diet type impacts production performance of fattening lambs by manipulating the ruminal microbiota and metabolome. Frontiers in microbiology. 2022, 4. Q1, 2Top, IF= 6.064.

6.Eunyoung Kim, Jiamei Cui, Guiguo Zhang*, Yunkyoung Lee* Physiological Effects of Green‐Colored Food‐Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases Applied Science. 2022,12,1879. 3, IF=2.679.

7.Chongyu Zhang, Chen Zhang, Yunpeng Wang, Meiyu Du, Guiguo Zhang*, Yunkyoung Lee* Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome Frontiers in veterinary science. 2021, 8, 694,357. Q1, 2, IF= 3.471.

8.Zemin Li, Chen Zhang, Shimin Zhang, Bo Li, Chong-Yu Zhang, Fawaz G Haj, Guiguo Zhang*, Yunkyoung Lee* The Intestinal Microbiota Characteristics of Salmonella-challenged Broilers and the Modulatory Effects of Alfalfa Polysaccharide on Intestinal Health. Scientific Reports.2021,11:10910. 3, IF= 4.379.

9.Chen Zhang, Chongyu Zhang, Meiyu Du, Yunpeng Wang, Guiguo Zhang*,Yunkyoung Lee* Effects of dietary supplementation with different fermented feeds on performance, nutrient digestibility, and serum biochemical indexes of fattening lambs. Animal Bioscience. 2021.34.4:633-641. Q1, IF=2.509.

10.Eunyoung Kim, Jiamei Cui, Inhae Kang, Guiguo Zhang*, Yunkyoung Lee* Potential Antidiabetic Effects of Seaweed Extracts by Upregulating Glucose Utilization and Alleviating Inflammation in C2C12 Myotubes. 2021 International Journal of Environmental Research and Public Health. Q1, 3 Top, IF= 3.390.

11.A-Reum Han, Jae-Hoon Kim, Eunyoung Kim, Jiamei Cui, In-suk Chai, Guiguo Zhang,* Yunkyoung Lee* Hypotriglyceridemic effects of brown seaweed consumption via regulation of bile acid excretion and hepatic lipogenesis in high fat diet-induced obese mice. Nutrition Research and Practice. 2020, 14, 6, 580-592. IF=1.792.

12.Chen Zhang, Zemin Li, Chong-Yu Zhang, Mengmeng Li, Yunkyoung Lee, Guiguo Zhang* Extract Methods, Molecular Characteristics, and Bioactivities of Polysaccharide from Alfalfa (Medicago sativa L.) Nutrients. 2019,11 (5)1181-1196. 2 Top, IF= 4.171.

13.Hyo-Seon Yang, Fawaz G Haj, Myoungsook Lee, Inhae Kang, Guiguo Zhang, Yunkyoung Lee*. Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells Nutrients. 2019,11,1001 2Top, IF= 4.171.

14.Zhang, C Y, Gan, L P, Du M Y, Shang, Q H, Xie, Y H, Zhang, G G*   Effects of dietary supplementation of alfalfa polysaccharides on growth performance, small intestinal enzyme activities, morphology, and large intestinal selected microbiota of piglets.  Livestock Science 2019. 223, 47-52.

15.Lixue Wang, Yuhuai Xie, WeirenYang, ZaibinYang, shuzhen Jiang, Chongyu Zhang & Guiguo Zhang*. Alfalfa polysaccharide prevents H₂O₂-induced oxidative damage in MEFs by activating MAPK/Nrf2 signaling pathways and suppressing NF-κB signaling pathways.Scientific Reports, 2019, 9:1782 （the corresponding author）（SCI, IF= 4.61）

16.Y.H. Xie, C.Y. Zhang, L.X. Wang, Q.H. Shang, G.G. Zhang*, W.R. Yang.  Effects of dietary supplementation of Enterococcus faecium on growth performance, intestinal morphology, and selected microbial populations of piglets. Livestock science   2018,210, 111-117， （SCI, IF= 1.79）（the corresponding author）

17.J. Zhang, B.J.Yin, Y.H.Xie, J. LI, Z. B. Yang, and G. G. Zhang*   Legume-cereal intercropping improves forage yield, quality and degradability Plos One 2015.12DOI:10.1371/journal.pone.0144813 （SCI, IF= 3.36）

18.G. G. Zhang, Z. B. Yang, Y. Wang, W. R. Yang and H. J. Zhou.   Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities, and large intestinal selected microbiota in weanling pigs.   J. Anim. Sci. 2014.92:2063–2069. （SCI, IF= 2.604）

19.Mengmeng Li, G. G. Zhang*,X.Z.Sun, S.O.Hoskin. New Zealand Studies on Methane Emissions from Pastoral Farming. Journal of Integrative Agriculture. 13(2): 365-377, 2014.（SCI, IF= 0.671）

20.Guiguo Zhang, Chongyu Zhang, Zaibin Yang，Shuting Dong. Root Distribution and N Acquisition in an Alfalfa and Corn Intercropping System. Journal of Agricultural Science. 5(9) 128-142, 2013. (SCI, IF=2.878）

21.G.G. Zhang, Z.B. Yang, Y. Wang, W.R. Yang.Effects of Astragalus Membranaceus Root Processed to Different Particle Sizes on Growth Performance, Antioxidant Status and Serum Metabolites of Broiler Chickens. Poultry Science. 92,178-183, 2013.（SCI, IF=1.516）

22.Guiguo Zhang, ZaibinYang，Qingqing Zhang.A multi-enzyme preparation enhances the utilization of  nutrients and energy from pure corn and wheat diets in broilers. Applied Poultry Research,1,67-78, 2012.（SCI, IF =0.846）

23Guiguo Zhang, ZaibinYang, Shuting Dong. Interspecific competitiveness affects the total biomass yield in an alfalfa and corn intercropping system. Field Crops Research, 124,66-73, 2011.（SCI, IF=2.774）

著作

《种草养畜禽关键技术彩图详解》 化学工业出版社  中国北京 2022 主编；

《图说健康养蛋鸭关键技术》 化学工业出版社  中国北京 2014  主编；

《图说健康养肉鸭关键技术》 化学工业出版社  中国北京 2014  主编；

《山羊标准化规模养殖图册》 中国农业出版社  中国北京 2012  副主编；

《绵羊标准化规模养殖图册》 中国农业出版社  中国北京 2012  副主编；