浏览次数：16239
职称：教授（三级、1512人才工程二层次）
办公室电话：0538-8242478
教育经历
2002 - 2005, 理学博士 , 兽医病理学 , 中国农业大学动物医学院
1984 - 1987, 理学硕士 , 兽医病理学 , 内蒙古农业大学动物医学院
1979 - 1983, 理学学士 , 兽医专业 , 山东农学院畜牧兽医系兽医专业
工作经历
2002 - 至今 , 教授 , 山东农业大学威尼斯wns·8885556
1996 - 2001 , 副教授 , 山东农业大学威尼斯wns·8885556
1992 - 1995 , 讲师 , 山东农业大学威尼斯wns·8885556
1987 - 1991, 助教 , 山东农业大学威尼斯wns·8885556
荣誉奖励
山东省星火计划一等奖（第三位），1998
山东省科技进步二等奖（第二位），2015
山东省科技进步三等奖（第一位），2003
执教课程
兽医病理学（本科生）
兽医临床病理学（本科生）
高级动物病理学（研究生）
家畜疾病案例分析（研究生）
研究领域
主要研究领域
1. 猪病流行病学调查、致病机制、综合诊断及防治技术研究
2. 禽病流行病学调查、致病机制、综合诊断及防治技术研究
3. 反刍动物流行病学调查、致病机制、综合诊断及防治技术研究
20多年来重点研究了我国畜禽重要流行性疾病及新发病的流行病学、病变变化、发病机制、诊断方法及防控技术，揭示了近年来畜禽重要疫病的流行规律、病原因素、致病机制、病变特征及综合防控，为我国畜禽业健康养殖做出了一定贡献。
主持的科研项目
1.规模化猪场科学合理的免疫程序的研究，国家重点研发计划-课题，2017-2021，经费310万元；
2.鸭坦布苏病毒的传播与致病的分子机制，国家重点研发计划-子课题，2016-2020，经费102万元；
3. 不同致瘤型ALV-J致瘤机制的分子病理学研究，国家自然基金面上项目，2012-2015，经费60万元；
4.突变p53蛋白对ALV-J感染与致瘤作用的影响及其分子病理机制研究，国家自然基金面上项目，2017-2021，经费80万元；
5. 禽白血病流行病学调查及抗ALV-J感染药物的研发及应用，农业公益性行业科研专项子课题，2012-2016，经费24万元；
6. 山东省现代农业产业创新团队岗位专家-牛疫病防控，山东省政府，2013-2020，经费200万元；
7. 山东部分地区禽流感免疫监测预警及流行病学调查，山东省农业厅，2016-2018，经费40万元；
8. 生猪健康养殖技术集成及产品供应链可追溯系统的建立与示范，山东省农业重大应用技术创新项目，2019-2021，经费40万元；
9. IBR与BVD流行病学调查及共感染协同致病机制，山东省重点研发计划，2018-2019，经费20万元；
10. 鸭黄病毒感染不同日龄鸭的病理变化及致病机制的研究，高等学校博士点基金博导类课题，2013-2015，经费12万元。
发表文章、专利
1. Li G, Yu G, Niu Y, Cai Y, Liu S. Airborne Transmission of a Serotype 4 Fowl Adenovirus in Chickens. Viruses. 2019;11(3).
2.Li N, Lv C, Yue R, Shi Y, Wei L, Chai T, Liu S. Effect of age on the pathogenesis of duck tembusu virus in Cherry Valley ducks. Front Microbiol. 2015;6:581.
3．Hu D, Lv L, Gu J, Chen T, Xiao Y, Liu S. Genetic Diversity and Positive Selection Analysis of Classical Swine Fever Virus Envelope Protein Gene E2 in East China under C-Strain Vaccination.Front Microbiol. 2016;7:85.
4. Niu Y, Sun Q, Zhang G, Sun W, Liu X, Xiao Y, Liu S. Epidemiological investigation of outbreaks of fowl adenovirus infections in commercial chickens in china. Transbound Emerg Dis.2017; 1–6.
5. Niu Y, Sun Q, Zhang G, Sun W, Liu X, Xiao Y, Shang Y, Liu S. Epidemiological investigation of outbreaks of fowl adenovirus infections in commercial chickens in China. Transbound Emerg Dis. 2018 ;65(1):e121-e126.
6.Gu J, Hu D, Peng T, Wang Y, Ma Z, Liu Z, Meng F, Shang Y, Liu S, Xiao Y. Epidemiological investigation of pseudorabies in Shandong Province from 2013 to 2016. Transbound Emerg Dis. 2018;65(3):890-898.
7. Niu Y, Sun W, Zhang G, Qu Y, Wang P, Sun H, Wang L, Xiao Y, Liu S. Hydropericardium syndrome outbreak caused by fowl adenovirus serotype 4 in China in 2015. J Gen Virol. 2016 ;97(10):2684-2690.
8. Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017;7(1):13554.
9. Li Y, Li J,Wang Z and Liu S. Study on Hsp90 Expression in Different Tissues and Its Antibody in Serum of Chickens Infected with Marek's Diseases. J.Integr.Agr.2014; 13(6): 1355-1362.
10. Niu Y, Sun Q, Zhang G, Liu X, Shang Y, Xiao Y, Liu S. Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver. Vet Microbiol.2018;223:34-41.
11. Li Y, Ma Z, Liu M, Cao L, Zhang J, Jiao Q, Meng F, Tong Z, Hu S, Jiang Z, Yang Y, Li B, Liu S. Porcine circovirus 3 in cattle in Shandong province of China: A retrospective study from 2011 to 2018. Vet Microbiol.2020;248:108824.
12. Cheng Z, Liu M, Wang P, Liu P, Chen M, Zhang J, Liu S, Wang F. Characteristics and Epidemiological Investigation of Paratuberculosis in Dairy Cattle in Tai'an, China. Biomed Res Int. 2020;2020:3896754.
13. Lv C, Li R, Liu X, Li N, Liu S. Pathogenicity comparison of duck Tembusu virus in different aged Cherry Valley breeding ducks. BMC Vet Res. 2019;15(1):282.
14. Qu Y, Liu L, Niu Y, Qu Y, Li N, Sun W, Lv C, Wang P, Zhang G, Liu S. Viral proliferation and expression of tumor-related gene in different chicken embryo fibroblasts infected with different tumorigenic phenotypes of avian leucosis virus subgroup J. Poult Sci. 2016;95(10):2383-90.
15. Niu Y, Sun Q, Zhang G, Sun W, Liu X, Xiao Y, Shang Y, Liu S. Pathogenicity and immunosuppressive potential of fowl adenovirus in specific pathogen free chickens. Poult Sci. 2017;96(11):3885-3892.
16. Niu Y, Sun Q, Zhu M, Zhao J, Zhang G, Liu X, Xiao Y, Liu S. Molecular epidemiology and phylogenetic analysis of fowl adenoviruses caused hydropericardium outbreak in China during 2015. Poult Sci. 2018;97(3):803-811.
17. Niu Y, Sun Q, Liu X, Liu S. Mechanism of fowl adenovirus serotype 4-induced heart damage and formation of pericardial effusion. Poult Sci. 2019;98(3):1134-45.
18. Niu Y, Sun Q, Shi Y, Ding Y, Li Z, Sun Y, Li M, Liu S. Immunosuppressive potential of fowl adenovirus serotype 4. Poult Sci. 2019;98(9):3514-3522.
19. Li Y, Liu M, Sun Q, Zhang H, Zhang H, Jiang S, Liu S, Huang Y. Genotypic evolution and epidemiological characteristics of H9N2 influenza virus in Shandong Province, China. Poult Sci. 2019;98(9):3488-3495.
20. Hu D, Meng F, Cui Y, Yin M, Ning H, Yin Z, Chen L, Ge Y, Liu S. Growth and cardiovascular development are repressed by florfenicol exposure in early chicken embryos.Poult Sci. 2020;99(5):2736-2745.
21. Zhang H, Zhang H, Cao S, Sui C, Song Y, Zhao Y, Liu S. Knockout of p53 leads to a significant increase in ALV-J replication. Poult Sci. 2021;100(10):101374.
22. Wang F, Yuan X, Wang Y, Zhang C, Xu L, Liu S. Cloning, Prokaryotic Expression, and Antigenicity Analysis of NS1 Gene of H9N2 Swine Influenza Virus. Agr Sci China. 2008;7(7):895-900.
23. Qu Y, Sun H, Sun M, Li D, Qin L, Gao Y, Wang X, Liu S. Sequence analysis for the complete proviral genome of avian leukosis virus subgroup J associated with haemangiomas, leiomyosarcomas and myelomas in layer flocks. Acta Vet Hung. 2012;60(3):343-54.
24. Liu L, Qu Y, Wang T, Wang G, Wang F, Liu S. Skin involvement in lymphomas caused by Marek's disease virus infection in Silkie chickens.J Vet Diagn Invest. 2014;26(2):302-725. Hu D, Zhang T, Zhang Z
, Wang G, Wang F, Qu Y, Niu Y, Liu S. Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol.Vet Immunol Immunopathol2014;162(3-4):122-31.
26. Wang X, Qiu H, Zhang M, Cai X, Qu Y, Hu D, Zhao X, Zhou E, Liu S, Xiao Y. Distribution of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in different stages of gestation sows: HP-PRRSV distribution in gestation sows. Vet Immunol Immunopathol 2015;166(3-4):88-94.
27. Hu D, Zhang Z, Lv L, Xiao Y, Qu Y, Ma H, Niu Y, Wang G, Liu S. Outbreak of variant pseudorabies virus in Bartha-K61-vaccinated piglets in central Shandong Province, China. J Vet Diagn Invest. 2015;27(5):600-5.
28. Zhang K, Xiao Y, Yu M, Liu J, Wang Q, Tao P, Liu S, Ning Z. Phylogenetic analysis of three orf virus strains isolated from different districts in Shandong Province, East China. J Vet Med Sci. 2016;77(12):1639-45.
29. Hu D, Han Z, Li C, Lv L, Cheng Z, Liu S. Florfenicol induces more severe hemotoxicity and immunotoxicity than equal doses of chloramphenicol and thiamphenicol in Kunming mice. Immunopharm Immunot. 2016;38(6):472-85.
30. Li N, Zhao J, Yang Y, Zeng Y, Liu S. Innate immune responses to duck Tembusu virus infection. Vet Res. 2020;51(1):87.
31. Cao S, Liu J, Ding G, Shao Q, Wang B, Li Y, Feng J, Zhao Y, Liu S, Xiao Y. The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε. Vet Res. 2020;51(1):104.
32. Zhang H, Liu M, Zhang H, Cao S, Li Y, Jiang S, Song Y, Liu S. Detection of p53 mutation and serum monitoring alert caused by Marek's disease virus in poultry. BMC Vet Res. 2020;16(1):303.
33. Yang Y, Li L, Liu X, Jiang M, Zhao J, Li X, Zhao C, Yi H, Liu S, Li N. Quantitative Proteomic Analysis of Duck Embryo Fibroblasts Infected With Novel Duck Reovirus. Front Vet Sci. 2020;7:577370.
34. Ma Z, Liu M, Liu Z, Meng F, Wang H, Cao L, Li Y, Jiao Q, Han Z, Liu S. Epidemiological investigation of porcine circovirus type 2 and its coinfection rate in Shandong province in China from 2015 to 2018. BMC Vet Res. 2021;17(1):17.
35. Wang T, Chai W, Wang Y, Liu W, Huang Z, Chen L, Guo R, Dong Y, Liu M, Zheng Q, Liu G, Wang C, Guo WP, Liu S, Li L. First detection and phylogenetic analysis of porcine circovirus 3 in female donkeys with reproductive disorders. BMC Vet Res. 2021;17(1):308.