姓名：魏晴晴
职称：讲师
邮箱：weiqq@sdau.edu.cn
个人简介
魏晴晴，女，博士，讲师，2017年毕业于中国农业大学生物学院获理学博士学位，2018年入职山东农业大学威尼斯wns·8885556动物遗传育种与繁殖系。主要执教本科生动物分子生物学、动物生物技术课程。研究方向为动物遗传与生物技术，包括动物体细胞重编程及多能干细胞多能性维持的分子机制解析、畜禽重要性状的遗传机制解析等相关研究。主持山东省自然科学基金、省部共建草原家畜生殖调控与繁育国家重点实验室开放课题各1项，参与国家自然科学基金面上项目、农业生物育种重大项目课题、山东省重点研发良种工程课题各1项。以第一作者或参与作者在Journal of Cellular Physiology、Biology of Reproduction、Cell Proliferation、Poultry Science、Nature Communication、Stem Cell Reports、Protein Cell 等国际知名SCI期刊发表论文15篇。
教育经历
2019 - 2024 , 博士后 , 畜牧学, 山东农业大学威尼斯wns·8885556
2013 - 2017 , 理学博士 , 生物化学与分子生物学 , 中国农业大学生物学院
2010 - 2013 , 农学硕士 , 动物遗传育种与繁殖学 , 山东农业大学威尼斯wns·8885556
2006 - 2010 , 农学、文学双学士, 动物科学、英语专业，山东农业大学威尼斯wns·8885556
工作经历
2018 - 至今 , 讲师 , 山东农业大学威尼斯wns·8885556
执教课程
动物分子生物学（本科生）
动物生物技术（本科生）
研究领域
研究方向为动物遗传与生物技术，主要包括：
1.畜禽重要性状的遗传机制解析
2.动物体细胞重编程分子机制解析
3.多能干细胞的多能性维持及分化的机制解析
承担的科研项目：
1. 山东省自然科学基金，PRDM14在牛体细胞重编程中的功能初探，2019-07至2021-06，主持
2. 省部共建草原家畜生殖调控与繁育国家重点实验室开放课题，用2D或3D培养体系建立牛Formative PSCs，2021-01至2023-12，主持
3. 国家自然科学基金面上项目，雌激素上调鸡等级前卵泡颗粒细胞DHCR7表达的分子机制及功能分析，2023-01至2026-12，参与
4. 农业生物育种重大项目课题，畜禽水产高产、高繁新基因挖掘与育种价值评价，2023-2025，参与
5. 山东省重点研发计划良种工程课题，基于高通量基因编辑的抗病鸡种质创制；2024-2027，参与
发表文章、专利
1. Wei Q, Xu Y, Cui G, Sun J, Su Z, Kou X, Zhao Y, Cao S, Li W, Xu Y, Gao S. Male-pronuclei-specific granulin facilitates somatic cells reprogramming via mitigating excessive cell proliferation and enhancing lysosomal function. J Cell Physiol. 2024;239(8):e31295.
2. Hu L, Li D, Wei Q, Kang L, Sun Y, Jiang Y. Characterization of a novel IGFBP-2 transcript in the ovarian granulosa cells of chicken follicles: mRNA expression, function and effect of reproductive hormones and IGF1. Poult Sci. 2024;103(12):104501.
3. Su Z, Dong Y, Sun J, Wu Y, Wei Q, Liang Y, Lin Z, Li Y, Shen L, Xi C, Wu L, Xu Y, Liu Y, Yin J, Wang H, Shi K, Le R, Gao S, Xu X. RNA m6A modification regulates cell fate transition between pluripotent stem cells and 2-cell-like cells. Cell Prolif. 2024;57(9):e13696. doi: 10.1111/cpr.13696.
4. Cui G, Zhou J, Sun J, Kou X, Su Z, Xu Y, Liu T, Sun L, Li W, Wu X, Wei Q, Gao S, Shi K. WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis. Cell Mol Life Sci. 2023;80(8):218.
5. Yue L, Pei Y, Zhong L, Yang H, Wang Y, Zhang W, Chen N, Zhu Q, Gao J, Zhi M, Wen B, Zhang S, Xiang J, Wei Q, Liang H, Cao S, Lou H, Chen Z, Han J. Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells. Stem Cell Reports. 2020;15(2):529-545.
6. Zhang S, Chen T, Chen N, Gao D, Shi B, Kong S, West RC, Yuan Y, Zhi M, Wei Q, Xiang J, Mu H, Yue L, Lei X, Wang X, Zhong L, Liang H, Cao S, Belmonte JCI, Wang H, Han J.Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. Nat Commun. 2019;10(1):496.
7. Xiang J, Cao S, Zhong L, Wang H, Pei Y, Wei Q, Wen B, Mu H, Zhang S, Yue L, Yue G, Lim B, Han J. Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos. Protein Cell. 2018;9(8):717-728.
8. Zhong L, Mu H, Wen B, Zhang W, Wei Q, Gao G, Han J, Cao S. Long non-coding RNAs involved in the regulatory network during porcine pre-implantation embryonic development and iPSC induction. Sci Rep. 2018 Apr 27;8(1):6649.
9. Wei Q, Li R, Zhong L, Mu H, Zhang S, Yue L, Xiang J, Li E, Zhi M, Cao S, Han J. Lineage specification revealed by single-cell gene expression analysis in porcine preimplantation embryos. Biol Reprod. 2018;99(2):283-292.
10. Wei Q, Zhong L, Zhang S, Mu H, Xiang J, Yue L, Dai Y, Han J. Bovine lineage specification revealed by single-cell gene expression analysis from zygote to blastocyst. Biol Reprod. 2017;97(1):5-17.
11. Wang H, Xiang J, Zhang W, Li J, Wei Q, Zhong L, Ouyang H, Han J. Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells. Sci Rep. 2016;6:27256.
12. Yang C, Wei Q, Kang L, Tang H, Zhu G, Cui X, Chen Y, Jiang Y. Identification and Genetic Effect of Haplotypes in the Distal Promoter Region of Chicken CCT6A Gene Associated with Egg Production Traits. J Poult Sci. 2016;53(2):111-117.
13. Pei Y, Yue L, Zhang W, Wang Y, Wen B, Zhong L, Xiang J, Li J, Zhang S, Wang H, Mu H, Wei Q, Han J. Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming. Sci Rep. 2015;5:16539.
14. Zhu G, Kang L, Wei Q, Cui X, Wang S, Chen Y, Jiang Y. Expression and regulation of MMP1, MMP3, and MMP9 in the chicken ovary in response to gonadotropins, sex hormones, and TGFB1. Biol Reprod. 2014;90(3):57.
15. Wei Q, Zhu G, Cui X, Kang L, Cao D, Jiang Y. Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone. Gen Comp Endocrinol. 2013;189:15-23.